Selected Publications
Organelle Identity & Membrane Compartmentalization
Bäcker N, Ast J, Martorana D, Renicke C, Berger J, Mais CN, Christ M, Stehlik T, Heimerl T, Wernet V, Taxis C, Pane-Farre J, Bölker M, Klatt JM, Sandrock B, Schink KO*, Bange G*, Freitag J* (2025).
Peroxisomal core structures segregate diverse metabolic pathways.
Nature Communications, 16(1): 1802.
https://doi.org/10.1038/s41467-024-48105-4
Membrane Identity & Phosphoinositide Control
Spangenberg H, Sneeggen M, Mateo Tortola M, Valenzuela C, Chang YY, Stenmark H, Raiborg C, Schink KO* (2021).
A phosphoinositide and RAB switch controls early macropinocytosis.
bioRxiv
https://doi.org/10.1101/2021.11.03.467145
Schink KO*, Tan KW, Spangenberg H, Martorana D, Sneeggen M, Stevenin V, Enninga J, Campsteijn C, Raiborg C, Stenmark H (2021).
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes.
Nature Communications, 12(1): 6577.
https://doi.org/10.1038/s41467-021-26724-1
Tan KW, Nahse V, Campsteijn C, Brech A, Schink KO*, Stenmark H (2021).
JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes.
Journal of Cell Science, 134(14): jcs258495.
https://doi.org/10.1242/jcs.258495
Schink KO, Tan KW, Stenmark H (2016).
Phosphoinositides in Control of Membrane Dynamics.
Annual Review of Cell and Developmental Biology, 32: 143-171.
https://doi.org/10.1146/annurev-cellbio-111315-125349
Cancer Cell Invasion & Macropinocytosis
Zdżalik-Bielecka D, Poświata A, Kozik K, Jastrzębski K, Schink KO, et al. (2021).
The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion.
PNAS, 118(28): e2024596118.
https://doi.org/10.1073/pnas.2024596118
Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H*, Schink KO* (2019).
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.
Nature Communications, 10(1): 2850.
https://doi.org/10.1038/s41467-019-10651-y
Sneeggen M, Schink KO*, Stenmark H* (2019).
Tumor suppression by control of matrix metalloproteinase recycling.
Molecular & Cellular Oncology, 6(6): e1646606.
https://doi.org/10.1080/23723556.2019.1646606
Autophagy & Membrane Remodeling
Nähse V*, Raiborg C, Tan KW, Mork S, Torgersen ML, Wenzel EM, Nager M, Salo VT, Johansen T, Ikonen E, Schink KO*, Stenmark H* (2023).
ATPase activity of DFCP1 controls selective autophagy.
Nature Communications, 14(1): 4051.
https://doi.org/10.1038/s41467-023-31547-0
Nähse V*, Schink KO*, Stenmark H* (2024).
ATPase-regulated autophagosome biogenesis.
Autophagy, 20(1): 218-219.
https://doi.org/10.1080/15548627.2023.xxxxxx
Nähse V*, Stenmark H*, Schink KO* (2025).
Omegasomes control formation, expansion, and closure of autophagosomes.
BioEssays, 46(6): e2400038.
https://doi.org/10.1002/bies.202400038
Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2020).
ESCRT-mediated phagophore sealing during mitophagy.
Autophagy, 16(5): 826-841.
https://doi.org/10.1080/15548627.2019.1659618
Membrane Repair & Vesicle Biogenesis
Radulovic M, Schink KO, Wenzel EM, Nahse V, Bongiovanni A, Lafont F, Stenmark H (2018).
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival.
EMBO Journal, 37(21): e99753.
https://doi.org/10.15252/embj.201899753
Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nahse V, Carlson A, Brech A, Stenmark H, Raiborg C (2018).
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation.
Nature Communications, 9(1): 2932.
https://doi.org/10.1038/s41467-018-05345-1